Endocrine Abstracts

Background: Thyroid disease is associated with BMI with hyperthyroidism causing weight loss and hypothyroidism leading to weight gain. However, the relation of body weight distribution to thyroid function in euthyroid individuals is unclear. This study assessed body composition in euthyroid women.Methods: Euthyroid women (n=1072) from the Osteoporosis and Ultrasound Study (OPUS), a population based cohort study recruited participants from 5 Europe...

OPUS is a population-based prospective cohort study of post-menopausal women from five European cities. We investigated whether TSH, fT4 and fT3 are associated with fracture risk, bone mineral density (BMD) at hip and spine, bone formation (osteocalcin, procollagen type 1 N-terminal propeptide), bone resorption (N- and C-telopeptides of type 1 collagen, NTX, CTX), pulse rate, grip strength and balance. Vertebral fractures were determined at baseline and 6 years follow-up. Usin...

(This poster is based on OC33)...

T3-action is regulated by three iodothyronine deiodinases, which contain selenium in the active site. It is proposed that Se availability regulates thyroid function. OPUS is a European population-based prospective cohort study of post-menopausal women in which we showed thyroid function within the upper normal range is associated with reduced bone mineral density (BMD) and increased non-vertebral fracture risk. Using strict exclusion criteria we defined reference ranges for th...